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KMID : 1123920130270040431
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Korean Journal of Oriental Physiology and Pathology
2013 Volume.27 No. 4 p.431 ~ p.436
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Inhibition Effect of Taxilli Ramulus Extract on Osteoclast Differentiation and Bone Resorption
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Back Jong-Min
Kim Ju-Young
Lee Myeung-Su
Jeong Woo-Jin
Moon Seo-Young
Jeon Byung-Hoon
Oh Jae-Min
Choi Min-Kyu
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Abstract
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Bone homeostasis is maintained by co-ordination of bone-resorbing osteoclasts and bone-forming osteoblasts. Imbalance between osteoclasts and osteoblasts leads to many bone diseases such as osteoporosis, rheumatoid arthritis. Taxillus chinensis is a herb that has been widely used to improve bone health. However, the effect and mechanism of Taxillus chinensis extract on osteoclast differentiation and bone resportion has been unknown. Thus, We investigated the effect of Taxillus chinensis on expression of receptor activator of nuclear factor-kB ligand (RANKL)-induced osteoclast differentiation and bone resorption. Also, the action of Taxillus chinensis on mechanisms relating to osteoclast differentiation was studied. In this results, we identified that Taxillus chinensis significantly inhibited RANKL-induced osteoclast differentiation and bone resportion. Moreover, Taxillus chinensis was suppressed the activation of NF-kB in bone marrow macrophage treated RANKL and M-CSF. Taxillus chinensis was down-regulated the mRNA expression of c-Fos, nuclear factor of activated T-cells (NFAT)c1, osteoclast-associated receptor (OSCAR), tartrate-resistant acid phosphatase (TRAP). The cell adhesion-related molecules such as integrin av and integrin b3, and the filamentous actin (F-actin) rings of mature osteoclasts-related molecules such as dendritic cell-specific transmembrane preotein (DC-STAMP) and cathepsin K are also suppressed. Taken together, these results indicated that Taxillus chinensis will be a good candidate to treat osteoclast-mediated bone diseases
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KEYWORD
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Taxillus chinenesis, Osteoclast, Osteoporosis, Differentiation, Bone resorption
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